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Zosuquidar trihydrochloride
CAS No. 167465-36-3
Zosuquidar trihydrochloride ( LY-335979 trihydrochloride )
Catalog No. M12557 CAS No. 167465-36-3
A potent P-glycoprotein (P-gp) inhibitor with Ki of 60 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 36 | In Stock |
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| 5MG | 58 | In Stock |
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| 10MG | 81 | In Stock |
|
| 50MG | 340 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameZosuquidar trihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent P-glycoprotein (P-gp) inhibitor with Ki of 60 nM.
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DescriptionA potent P-glycoprotein (P-gp) inhibitor with Ki of 60 nM; fully restores sensitivity to vinblastine, doxorubicin, etoposide, and Taxol in CEM/VLB100 cells at 0.1 uM; enhances the antitumor activity of Taxol in a MDR human non-small cell lung carcinoma nude mouse xenograft model.Blood Cancer Phase 3 Discontinued
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SynonymsLY-335979 trihydrochloride
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PathwayMembrane Transporter/Ion Channel
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TargetP-glycoprotein
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RecptorP-gp(P-glycoprotein)
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number167465-36-3
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Formula Weight636.99
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Molecular FormulaC32H34Cl3F2N3O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESFC1([C@H]2[C@@H]1C3=C([C@@H](C4=CC=CC=C42)N5CCN(CC5)C[C@H](COC6=C7C=CC=NC7=CC=C6)O)C=CC=C3)F.Cl.Cl.Cl
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Chemical Name1-Piperazineethanol, 4-[(1a.alpha.,6.alpha.,10b.alpha.)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-.alpha.-[(5-quinolinyloxy)methyl]-, hydrochloride (1:3), (.alpha.R)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Slate DL, et al. Anticancer Res. 1995 May-Jun;15(3):811-4.
2. Dantzig AH, et al. Cancer Res. 1996 Sep 15;56(18):4171-9.
3. Dantzig AH, et al. J Pharmacol Exp Ther. 1999 Aug;290(2):854-62.
2. Dantzig AH, et al. Cancer Res. 1996 Sep 15;56(18):4171-9.
3. Dantzig AH, et al. J Pharmacol Exp Ther. 1999 Aug;290(2):854-62.
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